外国人研究者Prof. R. Keene教授講演会のお知らせ
Richard Keene教授(James Cook University, Australia)が18回配位化合物 の光物理化学、光化学国際会議に参加された後、東工大に短期滞在されていま す。いい機会ですので、中央大にきていただき講演していただくことになりました。
Keene教授は、錯体化学が専門でルテニウム錯体の立体化学、混合原子価多核 錯体の研究を続けてこられました。
今回は最近興味をもって研究を進めて居られるDNAと多核ルテニウム錯体との相 互作用について講演していただく予定です。
多数ご参集ください。
======== Richard Keene教授講演会 ===========
講演者 Professor Richard Keene
School of Pharmacy & Molecular Sciences
James Cook University、Townsville, Queensland, Australia
日時 2009年7月21日(火)午後4時から約1時間30分
場所 3号館9階 3907号室
講演題目 Metal Complexes as Structure-Selective Binding Agents for Nucleic Acids
講演内容
Non-duplex secondary structure in nucleic acids is diverse, and has been extensively studied in
RNA. However, DNA also contains these structural elements ? which include base bulges,
hairpins, telomeres (including quadruplexes) and Holliday junctions. Such features can be
produced in DNA during replication and recombination, leading to the formation of defects that
may result in a variety of diseases and cancers.
As our knowledge of the structure and biological role of nucleic acids increases, so does the interest
in the development of small molecules that can regulate DNA and RNA function. While
considerable effort has been devoted to synthesising compounds that can target specific DNA and
RNA sequences, there is growing interest in developing agents that can recognise nucleic acid
structural features. There have been a number of studies of the interaction of mononuclear metal
complexes with DNA, but studies of polymetallic species are very limited. The latter have distinct
potential advantages in terms of greater levels of selectivity due to their increased size, range of
shapes and stereochemical diversity. Our own studies have shown that bulky dinuclear ruthenium
complexes associate weakly with the minor groove of duplex DNA, but demonstrate a significantly
greater affinity for more open and/or flexible secondary structures such as bulges and hairpins.
The seminar will describe fluorescence, NMR and modelling studies which elucidate the nature of the binding of dinuclear
complexes with DNA and RNA, and the features which allow structural selectivity ? with the potential consequences
of developing diagnostic agents or targeting structural features for clinical use in terms of drug design.
The specificity of the metal complex/DNA interaction may be applied in the “reverse” fashion by
using the DNA structures as ligands in affinity chromatography to discriminate (and therefore
separate) stereoisomers of metal complexes. This technique is remarkably efficient and will be
described in the presentation.
【ref】“Metal Complexes as Structure-Selective Binding Agents for Nucleic Acids”, F.R.Keene, J.A. Smith and J.G. Colllins,
Coord. Chem. Rev. 2009, in press (doi:10.1016/j.ccr.2009.01.004).
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