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題目:Studies on Non-covalent DNA Binding and Anticancer Activities of Mixed Ligand Copper(II) and Ruthenium(II) Complexes of Diimines
(銅(II)およびルテニウム(II)のジイミン混合配位子錯体とDNAとの非共有的結合と抗癌活性)
講演者:Prof. Mallayan Palaniandavar (インド,パラチダサン大学)
Prof. Mallayan Palaniandavar(インド,パラチダサン大学)が来日される機会に,最近その応用が注目されている銅(II)およびルテニウム錯体の抗癌活性と,これらの基礎となるDNAとの相互作用に関してご講演をお願いしました.是非ご参集ください.
アブストラクト:
A precise understanding of the DNA binding properties of metal complexes are driven by numerous motivations, which include therapeutic approaches, study of nucleic acid conformations and new tools for nanotechnology. The designing of non-covalent DNA binding anticancer drugs is growing in interest in the field of metallopharmaceuticals because the covalently DNA binding anticancer agent cisplatin possesses inherent limitations such as low degree of selectivity, high toxicity and low administration dosage. The non-covalent DNA-binding metallobleomycins are a widely-studied family of glycopeptide antibiotics that have been used successfully in the treatment of some forms of cancer. So, there is considerable attention focused on the design of new metal-based drugs that exhibit enhanced selectivity and novel modes of DNA interaction like non-covalent interactions that mimic the mode of interaction of proteins with DNA. In particular, the non-covalently DNA binding and cleaving mixed ligand biocompatible Cu(II) and Ru(II) complexes have received considerable attention during the past few years in an attempt to replace cisplatin. In mixed ligand complexes both the primary and co-ligands play a major role in tuning their DNA binding and cleavage properties.
A great deal of our present investigation involves synthesis of certain well-defined mixed ligand mononuclear Cu(II) and Ru(II) complexes of bi-, tri- and tetradentate ligands as primary ligands and a series of ‘affinity’ diimine ligands. The interaction of the complexes with DNA has been studied by a number of techniques including gel electrophoresis. The cytotoxicities of the complexes have been screened against cell lines of different origins. The results of our systematic investigation will be presented.
連絡先:中央大学理工学部学部応用化学学科
千喜良 誠
電話: 03-3817-1897