【理工研セミナー】Synthesis, characterization and nucleolytic property of bis(N,N’-dimethylglycinato)copper(II) (修飾アミノ酸銅(II)錯体のDNA切断活性について)
講演者:Dr. Ng Chew Hee(Malysia, Department of Biosciences & Chemistry, Universiti Tunku Abdul Rahman)
Dr. Ng Chew Hee(Malaysia, Department of Biosciences & Chemistry, Universiti Tunku Abdul Rahman)が来日される機会に,最近注目されている修飾アミノ酸銅(II)錯体のDNA切断活性についてご講演をお願いしました.是非ご参集ください.
講演概要:
Aquabis(N,N-dimethylglycinato)copper(II) dihydrate, [Cu(dmg)2(H2O)]?2H2O, was synthesized and characterized by elemental anal., FTIR, magnetic data, thermal anal., soln. UV-visible spectroscopy, x-ray crystal structure anal. and electrospray ionization mass spectroscopy. The square pyramidal copper(II) complex crystallizes in the orthorhombic space group P212121. The complex cleaves circular plasmid DNA (pBR322) in the presence of H2O2. The extent of cleavage varies with the concn. range of the complex, the type of buffer used, pH of buffer and the concn. of H2O2. Hydroxyl radical scavenger can inhibit the nucleolytic ability of this complex.
講演終了後,懇親会を予定しております.
連絡先:中央大学理工学部学部応用化学科学科
大石 克嘉
電話:03-3817-1903