生命科学専攻修士課程1年 宮下貴弘さんが生命医薬情報連合大会にてポスター賞を受賞しました
理工学研究科修士課程生命科学専攻1年宮下貴弘さん(岩舘研究室)が下記学会においてポスター賞を受賞しました。
【学会名】
生命医薬情報学連合大会
Joint Conference on Informatics in Biology, Medicine and Pharmacology
【開催日・会場】
2012年10月14日~17日
タワーホール船堀
【受賞研究タイトル】
Optimization for placement of secondary structures and multiple consensus selection for structures obtained from homology modeling
【著者】
Takahiro Miyashita, Wataru Sato, Hideaki Umeyama and Mitsuo Iwadate
【概要】
We introduced the combination of three consensus methods to select the accurate model from
large number of protein model structures obtained from homology modeling method. The first is a
method connected to GDT_TS calculation, the second is a method connected to secondary
structure evaluation, and the third is a method connected to the relative position of secondary
structures.
Then Re-packing program was developed to optimize the relative arrangement of helices and
sheets. The model is reconstructed after selecting a best model. The optimization is based on
atomic surface fitting between contacting two secondary structures. Therefore application for
overall protein structure brings small coordinate changes about protein size. The accuracy of minor
correction is evaluated in CASP10 targets.
ご興味をお持ちの方は以下のリンク先をご覧ください。