セミナーのお知らせ
スピーカー:Dr. M. Michael Gromiha
(生命情報工学研究センター 分子機能計算チーム 主任研究員)
Title:
Energy based approach for understanding the recognition mechanism of protein complexes
Abstract:
Understanding the recognition mechanism of proteins complexed with other molecules is a challenging task in molecular and computational biology. In this talk, I briefly discuss about the principles of existing methods and the novelty of the present approach for defining the binding sites. We have identified the important residues for binding and compared with experimental binding free energy change. The binding sites have been analyzed with various sequence and structure based parameters, which can be used for prediction. Further, we propose recognition mechanisms for protein-protein and protein-RNA complexes.
References:
M.M. Gromiha et al. (2009) Mol. Biosystems 5, 1779-1786.
M.M. Gromiha et al. (2010) Int. J. Biol. Macromol. 46, 187-192.
M.M. Gromiha et al. (2010) Curr. Protein Pept. Sci. (in press).
連絡先:中大物理 田口善弘(下記参照)
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Y-h. Taguchi, Dept. Phys., Chuo Univ., Kasuga, Bunkyo-ku, Tokyo 112-8551,Japan
Tel./Fax. +81-3-3817-1791/1792
http://www.granular.com/tag/index-j.html
〒112-8551 中央大学理工学部 物理学科 田口善弘 電話/FAX 03-3817-1791/1792